Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002683)
Formula
SVG example
Reactant 17beta-Estradiol-3,17-beta-sulfate Product Estrone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013308 E-3A 17beta-Estradiol-3,17-beta-sulfate Unclear E-3A [1]
MR002624 Estradiol 17beta-Estradiol-3,17-beta-sulfate Unclear Estradiol acetate [1]
MR002647 Estradiol 17beta-Estradiol-3,17-beta-sulfate Unclear Estradiol cypionate [1]
MR002670 Estradiol 17beta-Estradiol-3,17-beta-sulfate Unclear Estradiol valerate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004101 Conjugated estrogens Estrone Reduction - Reduction Conjugated estrogens [2]
MR013320 E-3A Estrone Unclear E-3A [3]
MR004241 Estrone sulfate Estrone Unclear Estrone sulfate [4]
MR000967 Estropipate Estrone Unclear Estropipate [5]
MR003147 4-androstene-3,17-dione(AD) Estrone Unclear Dehydroepiandrosterone [6]
MR002636 Estradiol Estrone Unclear Estradiol acetate [3]
MR002659 Estradiol Estrone Unclear Estradiol cypionate [3]
MR002682 Estradiol Estrone Unclear Estradiol valerate [3]
MR000957 Estromustine Estrone Unclear Estramustine [7]
⏷ Show the Full List of MR
References
1 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
2 Conjugated estrogens and bazedoxifene
3 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
4 Estrone Sulfate Transport and Steroid Sulfatase Activity in Colorectal Cancer: Implications for Hormone Replacement Therapy
5 DrugBank(Pharmacology-Metabolism)Estropipate
6 Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742.
7 Simultaneous determination of estramustine phosphate and its four metabolites in human plasma by liquid chromatography-ionspray mass spectrometry Biomed Chromatogr. 2004 Jun;18(5):293-301. doi: 10.1002/bmc.319.

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