Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002709)
Formula
SVG example
Reactant Zopiclone N-oxide Product 2-amino-5-chloropyridine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002711 Eszopiclone Zopiclone N-oxide Oxidation - N-Oxidation Eszopiclone [1]
MR009649 Zopiclone Zopiclone N-oxide Oxidation - N-oxidation Zopiclone [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002712 Eszopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [1]
MR002710 N-desmethylzopiclone 2-amino-5-chloropyridine Unclear Eszopiclone [1]
References
1 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Distribution of zopiclone and main metabolites in hair following a single dose

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