Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009649)
Formula
CYP3A4 ...
SVG example
N-oxidation
Reactant Zopiclone Product Zopiclone N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009650 Zopiclone Carbon dioxide Oxidation - Oxidative decarboxylation Zopiclone [1]
MR009651 Zopiclone N-desmethylzopiclone Oxidation - N-demethylation Zopiclone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002711 Eszopiclone Zopiclone N-oxide Oxidation - N-Oxidation Eszopiclone [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002709 Zopiclone N-oxide 2-amino-5-chloropyridine Unclear Eszopiclone [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Distribution of zopiclone and main metabolites in hair following a single dose
3 Development of a novel tandem mass spectrometry method for the quantification of eszopiclone without interference from 2-amino-5-chloropyridine and application in a pharmacokinetic study of rat J Pharm Biomed Anal. 2020 Sep 5;188:113363. doi: 10.1016/j.jpba.2020.113363.

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