Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002798)
Formula	CYP2C19 ... N-Demethylation
	Reactant	Adinazolam		Product	Desmethyladinazolam
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	Mephenytoin 4-hydroxylase (CYP2C19)					DME Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)					DME Info
Metabolic Type	Oxidation - N-Demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002799	Adinazolam	Alpha-hydroxyalprazolam	Unclear	Adinazolam	[1]
MR002801	Adinazolam	Estazolam	Unclear	Adinazolam	[1]
MR002800	Adinazolam	N-demithyladinazolam	Unclear	Adinazolam	[1]

References
1	Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar;50(3):265-74.

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