Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002890)
Formula
SVG example
N-Dealkylation
Reactant Selegiline hydrochloride Product Levmetamfetamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002889 Selegiline hydrochloride Desmethylselegiline Oxidation - N-Dealkylation Selegiline hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002891 Levmetamfetamine Levamfetamine Oxidation - N-Dealkylation Selegiline hydrochloride [1]
References
1 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
2 Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. J Anal Toxicol. 2021 Feb 6;45(1):99-104. doi: 10.1093/jat/bkaa058.

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