Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002889)
Formula
SVG example
N-Dealkylation
Reactant Selegiline hydrochloride Product Desmethylselegiline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002890 Selegiline hydrochloride Levmetamfetamine Oxidation - N-Dealkylation Selegiline hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010843 Selegiline Desmethyl selegiline Unclear - Unclear Selegiline [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010844 Desmethyl selegiline Amphetamine Unclear - Unclear Selegiline [2]
MR002892 Desmethylselegiline Levamfetamine Unclear Selegiline hydrochloride [1]
References
1 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
2 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

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