Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002944)
Formula
CYP2D6 ...
SVG example
O-demethylation
Reactant Formoterol Product O-demethylated formoterol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002945 Formoterol Formoterol deformylated metabolite Unclear Formoterol [1]
MR002946 Formoterol Formoterol glucuronide metabolite 1 Conjugation - O-Glucuronidation Formoterol [1], [2]
MR002947 Formoterol Formoterol glucuronide metabolite 2 Conjugation - O-Glucuronidation Formoterol [1], [2]
MR002948 Formoterol Formoterol sulfate conjugate metabolite Conjugation - Sulfation Formoterol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002942 O-demethylated formoterol O-demethylated formoterol glucuronide metabolite 1 Unclear Formoterol [3], [2]
MR002941 O-demethylated formoterol O-demethylated formoterol glucuronide metabolite 2 Unclear Formoterol [3], [2]
References
1 Mass balance and metabolism of [(3)H]Formoterol in healthy men after combined i.v. and oral administration-mimicking inhalation Drug Metab Dispos. 1999 Oct;27(10):1104-16.
2 FDA Approved Drug Products: Perforomist? inhalation solution
3 DrugBank : Formoterol

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