Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002981)
Formula Reactant Acetoacetate Product Beta-hydroxybutyrate
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006972 HSDB-41 Acetoacetate Hydrolysis - Hydrolysis HSDB-41 [1]
MR002980 HMG-CoA Acetoacetate Unclear - Unclear Acetyl-CoA [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006973 Acetoacetate Acetoacetyl-CoA Unclear HSDB-41 [1]
References
1 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
2 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
3 Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders. Front Endocrinol (Lausanne). 2022 Oct 20;13:972890. doi: 10.3389/fendo.2022.972890.
4 In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation. Metabolites. 2021 Apr 28;11(5):279. doi: 10.3390/metabo11050279.

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