Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002980)
Formula
SVG example
Unclear
Reactant HMG-CoA Product Acetoacetate
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002977 Acetoacetyl-CoA HMG-CoA Unclear - Unclear Acetyl-CoA [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002978 HMG-CoA Mevalonate Unclear - Unclear Acetyl-CoA [1], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006972 HSDB-41 Acetoacetate Hydrolysis - Hydrolysis HSDB-41 [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006973 Acetoacetate Acetoacetyl-CoA Unclear HSDB-41 [4]
MR002981 Acetoacetate Beta-hydroxybutyrate Unclear - Unclear Acetyl-CoA [1], [2], [5]
References
1 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
2 Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders. Front Endocrinol (Lausanne). 2022 Oct 20;13:972890. doi: 10.3389/fendo.2022.972890.
3 Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis. Redox Biol. 2023 Jun 16;64:102771. doi: 10.1016/j.redox.2023.102771.
4 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
5 In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation. Metabolites. 2021 Apr 28;11(5):279. doi: 10.3390/metabo11050279.

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