Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006973)
Formula
SVG example
Reactant Acetoacetate Product Acetoacetyl-CoA
Reactant Info Product Info
Metabolic Enzyme 3-oxoacid CoA-transferase (scoAB) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006972 HSDB-41 Acetoacetate Hydrolysis - Hydrolysis HSDB-41 [1]
MR002980 HMG-CoA Acetoacetate Unclear - Unclear Acetyl-CoA [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002981 Acetoacetate Beta-hydroxybutyrate Unclear - Unclear Acetyl-CoA [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002976 Acetyl-CoA Acetoacetyl-CoA Oxidation - Beta Oxidation Acetyl-CoA [5], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002977 Acetoacetyl-CoA HMG-CoA Unclear - Unclear Acetyl-CoA [2], [3]
MR002982 Acetoacetyl-CoA Malonyl-CoA Unclear - Unclear Acetyl-CoA [2], [6], [7]
MR006974 Acetoacetyl-CoA Acetyl coenzyme A Unclear HSDB-41 [1]
References
1 The human gastric pathogen Helicobacter pylori has a potential acetone carboxylase that enhances its ability to colonize mice. BMC Microbiol. 2008 Jan 23;8:14.
2 Compartmentalised acyl-CoA metabolism and roles in chromatin regulation Mol Metab. 2020 Aug;38:100941. doi: 10.1016/j.molmet.2020.01.005.
3 Activation of G protein-coupled receptors by ketone bodies: Clinical implication of the ketogenic diet in metabolic disorders. Front Endocrinol (Lausanne). 2022 Oct 20;13:972890. doi: 10.3389/fendo.2022.972890.
4 In Vivo Estimation of Ketogenesis Using Metabolic Flux Analysis-Technical Aspects and Model Interpretation. Metabolites. 2021 Apr 28;11(5):279. doi: 10.3390/metabo11050279.
5 U. S. FDA Label -Acetyl-CoA
6 High throughput (13)C-metabolic flux analysis of 3-hydroxypropionic acid producing Pichia pastoris reveals limited availability of acetyl-CoA and ATP due to tight control of the glycolytic flux. Microb Cell Fact. 2023 Jun 29;22(1):117. doi: 10.1186/s12934-023-02123-0.
7 Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell Rep. 2023 May 30;42(5):112488. doi: 10.1016/j.celrep.2023.112488.

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