Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003098)
Formula
CBR1 ...
SVG example
Reduction
Reactant Fenofibric acid Product Reduced Fenofibric Acid
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 1 (CBR1) DME Info
Aldo-keto reductase 1C1 (AKR1C1) DME Info
Aldo-keto reductase 1C2 (AKR1C2) DME Info
Aldo-keto reductase 1C3 (AKR1C3) DME Info
Aldo-keto reductase 1B1 (AKR1B1) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003100 Fenofibric acid Fenofibrate metabolite X Conjugation - Methylation Fenofibric acid [1]
MR003099 Fenofibric acid Fenofibryl glucuronide Conjugation - Glucuronidation Fenofibric acid [2]
MR003096 Fenofibric acid Fenofibrate metabolite X Conjugation - Methylation Fenofibrate [1]
MR003095 Fenofibric acid Fenofibryl glucuronide Conjugation - Glucuronidation Fenofibrate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003097 Reduced Fenofibric Acid Reduced Fenofibric Acid glucuronide Conjugation - O-Glucuronidation Fenofibric acid [3]
MR003092 Reduced Fenofibric Acid Reduced Fenofibric Acid glucuronide Conjugation - O-Glucuronidation Fenofibrate [3]
References
1 Fenofibrate: metabolism and species differences for peroxisome proliferation in cultured hepatocytes Fundam Appl Toxicol. 1995 Jun;26(1):63-74. doi: 10.1006/faat.1995.1075.
2 The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem. 2003 Apr 18;278(16):13975-83.
3 In vitro metabolism of fenofibric acid by carbonyl reducing enzymes. Chem Biol Interact. 2016 Oct 25;258:153-8.

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