Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003102)
Formula
SVG example
N-Dealkylation
Reactant Leflunomide Product A77 1726
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003105 Leflunomide . Unclear Leflunomide [1]
MR003104 Leflunomide 5-Methylisoxazole carboxylic acid Oxidation - Deamination Leflunomide [2]
MR003103 Leflunomide Trifluoromethylaniline Oxidation - Deamination Leflunomide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003101 A77 1726 Leflunomide metabolite M1 Unclear Leflunomide [3]
References
1 Leflunomide-induced acute hepatitis. Dig Liver Dis. 2004 Jan;36(1):82-4.
2 In vitro metabolism of leflunomide by mouse and human liver microsomes Drug Metab Lett. 2007 Dec;1(4):299-305. doi: 10.2174/187231207783221402.
3 A redox-mediated Kemp eliminase Nat Commun. 2017 Mar 28;8:14876. doi: 10.1038/ncomms14876.

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