General Information of This Metabolic Reaction (MR) (ID: MR003127)
Formula
CYP3A4 ...
SVG example
Demethylation
Reactant Cariprazine hydrochloride Product Didesmethyl cariprazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003126 Cariprazine hydrochloride Desmethyl cariprazine Oxidation - Demethylation Cariprazine hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003125 Desmethyl cariprazine Didesmethyl cariprazine Oxidation - Demethylation Cariprazine hydrochloride [1]
References
1 Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):193-206.

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