Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003156)
Formula
SVG example
Oxidative Dehydrogenation
Reactant Oxymetazoline Product Oxymetazoline metabolite M2
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidative Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003157 Oxymetazoline Oxymetazoline metabolite M8 Conjugation - Conjugation Oxymetazoline [1]
MR003158 Oxymetazoline Oxymetazoline O-glucuronidation Conjugation - O-Glucuronidation Oxymetazoline [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003152 Oxymetazoline metabolite M2 Oxymetazoline metabolite M3 Oxidation - Monohydroxylation Oxymetazoline [1]
MR003154 Oxymetazoline metabolite M2 Oxymetazoline metabolite M6 Conjugation - Conjugation Oxymetazoline [1]
MR003153 Oxymetazoline metabolite M2 Oxymetazoline metabolite M7 Conjugation - Conjugation Oxymetazoline [1]
References
1 In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite. Drug Metab Dispos. 2011 Apr;39(4):693-702.
2 Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9. J Pharm Sci. 2011 Feb;100(2):784-93.

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