Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003255)
Formula
SVG example
4-Hydroxylation
Reactant Propofol glucuronide Product 4-hydroxymethylpyrazole
Reactant Info Product Info
Metabolic Type Oxidation - 4-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002188 Propofol Propofol glucuronide Conjugation - Glucuronidation Propofol [1]
MR003262 Propofol Propofol glucuronide Conjugation - Glucuronidation Fospropofol [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002186 Propofol glucuronide 1-Quinol glucuronide Oxidation - 4-Hydroxylation Propofol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001086 Fomepizole 4-hydroxymethylpyrazole Unclear Fomepizole [2]
MR005975 GTPL-463 4-hydroxymethylpyrazole Unclear GTPL-463 [3]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear Fospropofol [4]
MR003254 4-Quinol sulfate 4-hydroxymethylpyrazole Conjugation - Glucuronidation Fospropofol [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 DrugBank(Pharmacology-Metabolism)Fomepizole
3 DrugBank(Pharmacology-Metabolism):GTPL-463 Fomepizole
4 DrugBank(Pharmacology-Metabolism)Fospropofol

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