Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003261)
Formula
CYP2C9 ...
SVG example
4-Hydroxylation
Reactant Propofol Product 4-hydroxypropofol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - 4-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002188 Propofol Propofol glucuronide Conjugation - Glucuronidation Propofol [1]
MR007843 Propofol 2-(omega-Propanol)-6-isopropyl-phenol Unclear - Unclear Fospropofol disodium [2]
MR003260 Propofol 4-hydroxymethylpyrazole Unclear Fospropofol [3]
MR003262 Propofol Propofol glucuronide Conjugation - Glucuronidation Fospropofol [1]
MR007850 Propofol Propofol-O-glucuronide Conjugation - O-glucuronidation Fospropofol disodium [2]
MR007849 Propofol Propofol-O-sulfate Unclear - Unclear Fospropofol disodium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002184 4-hydroxypropofol 1-Quinol glucuronide Conjugation - Glucuronidation Propofol [1]
MR002185 4-hydroxypropofol 4-Quinol glucuronide Conjugation - Glucuronidation Propofol [1]
MR002183 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Propofol [1]
MR007841 4-Hydroxypropofol 1-Hydroxypropofol-O-glucuronide Unclear - Unclear Fospropofol disodium [2]
MR007840 4-Hydroxypropofol 2,6-Diisopropyl-1,4-quinone Conjugation - O-glucuronidation Fospropofol disodium [2]
MR007838 4-Hydroxypropofol 2-(omega-Propanol)-6-isopropyl-1,4-quinol Unclear - Unclear Fospropofol disodium [2]
MR007842 4-Hydroxypropofol 4-Hydroxypropofol-O-glucuronide Unclear - Unclear Fospropofol disodium [2]
MR007836 4-Hydroxypropofol 4-Hydroxypropofol-O-sulphate Unclear - Unclear Fospropofol disodium [2]
MR003253 4-hydroxypropofol 4-Quinol sulfate Other reaction - Sulfonation Fospropofol [1]
⏷ Show the Full List of MR
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects
3 DrugBank(Pharmacology-Metabolism)Fospropofol

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