Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003300)
Formula Reactant Valdecoxib metabolite M9 Product Valdecoxib metabolite M9-G
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003303 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Valdecoxib [1]
MR003491 Valdecoxib Valdecoxib metabolite M9 Oxidation - Hydroxylation Parecoxib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003299 Valdecoxib metabolite M9 Valdecoxib metabolite M3 Unclear Valdecoxib [1]
MR003492 Valdecoxib metabolite M9 Valdecoxib metabolite M3 Unclear Parecoxib [1]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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