Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003303)
Formula Reactant Valdecoxib Product Valdecoxib metabolite M9
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003302 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Valdecoxib [1], [2]
MR003301 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Valdecoxib [1], [2]
MR003304 Valdecoxib Valdecoxib N-glucuronide Unclear Valdecoxib [1], [2]
MR003485 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Parecoxib [1], [2]
MR003480 Valdecoxib Valdecoxib metabolite M2 Oxidation - N-Oxidation Parecoxib [2]
MR003496 Valdecoxib Valdecoxib N-glucuronide Conjugation - Glucuronidation Parecoxib [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003299 Valdecoxib metabolite M9 Valdecoxib metabolite M3 Unclear Valdecoxib [1]
MR003300 Valdecoxib metabolite M9 Valdecoxib metabolite M9-G Unclear Valdecoxib [1]
MR003492 Valdecoxib metabolite M9 Valdecoxib metabolite M3 Unclear Parecoxib [1]
MR003493 Valdecoxib metabolite M9 Valdecoxib metabolite M9-G Unclear Parecoxib [1], [2]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.