Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003317)
Formula
CYP1A1 ...
SVG example
6-Hydroxylation
Reactant Melatonin Product 6-hydroxymelatonin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 6-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003316 Melatonin 5-Methoxytryptamine Oxidation - Deacetylation Melatonin [1]
MR003315 Melatonin Dihydroxy ketobemidone Oxidation - O-Demethylation Melatonin [1]
MR004013 Melatonin Melatonin Derivatives Unclear TRP-01 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003314 6-hydroxymelatonin 6-hydroxymelatonin sulfate metabolite Other reaction - Sulfonation Melatonin [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Tryptophan and indole metabolism in immune regulation

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