Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003315)
Formula
CYP1A2 ...
SVG example
O-Demethylation
Reactant Melatonin Product Dihydroxy ketobemidone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003316 Melatonin 5-Methoxytryptamine Oxidation - Deacetylation Melatonin [1]
MR003317 Melatonin 6-hydroxymelatonin Oxidation - 6-Hydroxylation Melatonin [1]
MR004013 Melatonin Melatonin Derivatives Unclear TRP-01 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001335 Ketobemidone Dihydroxy ketobemidone Unclear Ketobemidone [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001331 Dihydroxy ketobemidone M-hydroxymethoxy ketobemidone Unclear Ketobemidone [1]
MR003309 Dihydroxy ketobemidone N-Acetyl-5-hydroxytryptamine glucuronide metabolite Conjugation - Glucuronidation Melatonin [1]
MR003310 Dihydroxy ketobemidone N-Acetyl-5-hydroxytryptamine sulfate metabolite Other reaction - Sulfonation Melatonin [1]
MR001330 Dihydroxy ketobemidone p-hydroxymethoxy ketobemidone Unclear Ketobemidone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Tryptophan and indole metabolism in immune regulation

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.