Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003414)
Formula
SVG example
Oxidation
Reactant Sulfinpyrazone Product Sulfinpyrazone sulfone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003416 Sulfinpyrazone 4-hydroxy-sulfinpyrazone Oxidation - Hydroxylation Sulfinpyrazone [1]
MR003413 Sulfinpyrazone p-hydroxy sulfinpyrazone Oxidation - Hydroxylation Sulfinpyrazone [2], [1]
MR003415 Sulfinpyrazone Sulphide Oxidation - Oxidation Sulfinpyrazone [1]
References
1 Species differences in the disposition and metabolism of sulfinpyrazone Xenobiotica. 1981 Aug;11(8):559-68. doi: 10.3109/00498258109045867.
2 Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s. Drug Metab Dispos. 2001 May;29(5):701-11.

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