Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003450)
Formula Reactant Edoxaban Product Edoxaban metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003451 Edoxaban Edoxaban metabolite M1 Unclear Edoxaban [1]
MR003452 Edoxaban Edoxaban metabolite M2 Unclear Edoxaban [1]
MR003453 Edoxaban Edoxaban metabolite M3 Unclear Edoxaban [1]
MR003454 Edoxaban Edoxaban metabolite M4 Hydrolysis - Hydrolysis Edoxaban [1]
MR003449 Edoxaban Edoxaban metabolite M6 Unclear Edoxaban [1]
MR003447 Edoxaban Edoxaban metabolite M7 Unclear Edoxaban [1]
References
1 Pharmacokinetics, biotransformation, and mass balance of edoxaban, a selective, direct factor Xa inhibitor, in humans Drug Metab Dispos. 2012 Dec;40(12):2250-5. doi: 10.1124/dmd.112.046888.

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