Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003457)
Formula
SVG example
N-dealkylation
Reactant Alectinib metabolite M4 Product Alectinib metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003456 Alectinib metabolite M5 Alectinib metabolite M4 Oxidation - Oxidation Alectinib hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003460 Alectinib metabolite M5 Alectinib metabolite M6 Oxidation - N-dealkylation Alectinib hydrochloride [1]
References
1 In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes. Xenobiotica. 2018 Jun;48(6):546-554.

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