Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003499)
Formula
SVG example
Demethylation
Reactant Ipecac Product 9-O-demethylemetine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003501 Ipecac 10-O-demethylemetine Oxidation - Demethylation Ipecac [1], [2]
MR003497 Ipecac Cephaeline Oxidation - Demethylation Ipecac [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006986 Q-100155 9-O-demethylemetine Oxidation - Demethylation Q-100155 [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003500 9-O-demethylemetine 9-O-demethylemetine glucuronide metabolite Conjugation - Glucuronidation Ipecac [1]
References
1 Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82.
2 Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):29-35. doi: 10.1007/BF03190402.
3 Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.