Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003497)
Formula
CYP2D6 ...
SVG example
Demethylation
Reactant Ipecac Product Cephaeline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003501 Ipecac 10-O-demethylemetine Oxidation - Demethylation Ipecac [1], [2]
MR003499 Ipecac 9-O-demethylemetine Oxidation - Demethylation Ipecac [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003498 Cephaeline Cephaeline 6'-O-glucuronide metabolite Conjugation - Glucuronidation Ipecac [1]
References
1 Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82.
2 Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats Eur J Drug Metab Pharmacokinet. 2002 Jan-Mar;27(1):29-35. doi: 10.1007/BF03190402.

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