Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003532)
Formula
SVG example
Demethylation
Reactant Nintedanib metabolite M6 Product Nintedanib metabolite M4
Reactant Info Product Info
Metabolic Enzyme DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003531 Nintedanib esylate Nintedanib metabolite M6 Oxidation - Demethylation Nintedanib esylate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003535 Nintedanib metabolite M6 Nintedanib metabolite M15 Conjugation - Glucuronidation Nintedanib esylate [1]
MR003534 Nintedanib metabolite M6 Nintedanib metabolite M18 Conjugation - Acetylation Nintedanib esylate [1]
MR003536 Nintedanib metabolite M6 Nintedanib metabolite M3 Oxidation - Hydroxylation Nintedanib esylate [1]
MR003533 Nintedanib metabolite M6 Nintedanib metabolite M16 Conjugation - Acetylation Nintedanib esylate [1]
References
1 Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.

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