Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003531)
Formula
SULT1A1 ...
SVG example
Demethylation
Reactant Nintedanib esylate Product Nintedanib metabolite M6
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase 1A1 (SULT1A1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003544 Nintedanib esylate Nintedanib metabolite M12 Unclear Nintedanib esylate [1]
MR003547 Nintedanib esylate Nintedanib metabolite M13 Unclear Nintedanib esylate [1]
MR003537 Nintedanib esylate Nintedanib metabolite M5 Oxidation - Demethylation Nintedanib esylate [1]
MR003543 Nintedanib esylate Nintedanib metabolite M7 Conjugation - Glucuronidation Nintedanib esylate [1]
MR003546 Nintedanib esylate Nintedanib metabolite M8 Oxidation - Hydroxylation Nintedanib esylate [1]
MR003545 Nintedanib esylate Nintedanib metabolite M9 Unclear Nintedanib esylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003535 Nintedanib metabolite M6 Nintedanib metabolite M15 Conjugation - Glucuronidation Nintedanib esylate [1]
MR003534 Nintedanib metabolite M6 Nintedanib metabolite M18 Conjugation - Acetylation Nintedanib esylate [1]
MR003536 Nintedanib metabolite M6 Nintedanib metabolite M3 Oxidation - Hydroxylation Nintedanib esylate [1]
MR003532 Nintedanib metabolite M6 Nintedanib metabolite M4 Oxidation - Demethylation Nintedanib esylate [1]
MR003533 Nintedanib metabolite M6 Nintedanib metabolite M16 Conjugation - Acetylation Nintedanib esylate [1]
References
1 Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.

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