Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003540)
Formula
SVG example
Hydroxylation
Reactant Nintedanib metabolite M5 Product Nintedanib metabolite M2
Reactant Info Product Info
Metabolic Enzyme DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003537 Nintedanib esylate Nintedanib metabolite M5 Oxidation - Demethylation Nintedanib esylate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003539 Nintedanib metabolite M5 Nintedanib metabolite M1 Oxidation - Hydroxylation Nintedanib esylate [1]
MR003538 Nintedanib metabolite M5 Nintedanib metabolite M10 Oxidation - Decarbonylation Nintedanib esylate [1]
MR003542 Nintedanib metabolite M5 Nintedanib metabolite M11 Reduction - Reduction; Glycine addition Nintedanib esylate [1]
MR003541 Nintedanib metabolite M5 Nintedanib metabolite M14 Conjugation - Glucuronidation Nintedanib esylate [1]
References
1 Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.

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