Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003537)
Formula
SVG example
Demethylation
Reactant Nintedanib esylate Product Nintedanib metabolite M5
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003544 Nintedanib esylate Nintedanib metabolite M12 Unclear Nintedanib esylate [1]
MR003547 Nintedanib esylate Nintedanib metabolite M13 Unclear Nintedanib esylate [1]
MR003531 Nintedanib esylate Nintedanib metabolite M6 Oxidation - Demethylation Nintedanib esylate [1]
MR003543 Nintedanib esylate Nintedanib metabolite M7 Conjugation - Glucuronidation Nintedanib esylate [1]
MR003546 Nintedanib esylate Nintedanib metabolite M8 Oxidation - Hydroxylation Nintedanib esylate [1]
MR003545 Nintedanib esylate Nintedanib metabolite M9 Unclear Nintedanib esylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003539 Nintedanib metabolite M5 Nintedanib metabolite M1 Oxidation - Hydroxylation Nintedanib esylate [1]
MR003538 Nintedanib metabolite M5 Nintedanib metabolite M10 Oxidation - Decarbonylation Nintedanib esylate [1]
MR003542 Nintedanib metabolite M5 Nintedanib metabolite M11 Reduction - Reduction; Glycine addition Nintedanib esylate [1]
MR003541 Nintedanib metabolite M5 Nintedanib metabolite M14 Conjugation - Glucuronidation Nintedanib esylate [1]
MR003540 Nintedanib metabolite M5 Nintedanib metabolite M2 Oxidation - Hydroxylation Nintedanib esylate [1]
References
1 Metabolic pro?ling of tyrosine kinase inhibitor nintedanib using metabolomics J Pharm Biomed Anal. 2020 Feb 20;180:113045. doi: 10.1016/j.jpba.2019.113045.

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