Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003709)
Formula Reactant LAU-7b Product 4-HPR glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003708 LAU-7b 4'-hydroxy 4-HPR Unclear LAU-7b [1]
MR003704 LAU-7b 4'-oxo 4-HPR Unclear LAU-7b [1]
MR003711 LAU-7b 4-MPR Unclear LAU-7b [2]
MR003710 LAU-7b Dehydrogenated 4-HPR Unclear LAU-7b [2]
References
1 Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases. Br J Pharmacol. 2011 Feb;162(4):989-99.
2 Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure

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