Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003708)
Formula
CYP2C8 ...
SVG example
Reactant LAU-7b Product 4'-hydroxy 4-HPR
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003704 LAU-7b 4'-oxo 4-HPR Unclear LAU-7b [1]
MR003709 LAU-7b 4-HPR glucuronide Unclear LAU-7b [1]
MR003711 LAU-7b 4-MPR Unclear LAU-7b [2]
MR003710 LAU-7b Dehydrogenated 4-HPR Unclear LAU-7b [2]
References
1 Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases. Br J Pharmacol. 2011 Feb;162(4):989-99.
2 Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure

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