Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003858)
Formula Reactant Hesperetin Product Hesperetin-sulfo-O-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007030 Hesperetin Eriodictyol Oxidation - 4'-demethylation Hesperetin [1]
MR007031 Hesperetin Hesperetin 3p-O-Glucuronide Conjugation - Glucuronidation Hesperetin [2], [3]
MR007032 Hesperetin Hesperetin 7-O-glucuronide Conjugation - Glucuronidation Hesperetin [2], [3]
MR004485 Hesperetin 3-(3'-Hydroxy-4'-methoxyphenyl)-2-propionic acid Unclear VS-12343 [4]
References
1 DrugBank(Pharmacology-Metabolism):Hesperetin
2 BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
3 Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation
4 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium

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