Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003919)
Formula Reactant H3B-6527 Product H3B-68730
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-deethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003920 H3B-6527 H3B-6527 Metabolite M645 Unclear H3B-6527 [1]
MR003916 H3B-6527 H3B-6527 Metabolite M936 Unclear H3B-6527 [1]
References
1 Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study. Xenobiotica. 2020 Apr;50(4):458-467.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.