Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003953)
Formula
CYP3A4 ...
SVG example
Hydrolyzationn
Reactant MK-0822 Product MK-0822 Metabolite M8 (Odanacatib)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003963 MK-0822 MK-0822 Metabolite M1-A Unclear MK-0822 [1]
MR003962 MK-0822 MK-0822 Metabolite M10 (Odanacatib) Multi-steps Reaction - Glucuronidation; hydrolysis MK-0822 [2]
MR003958 MK-0822 MK-0822 Metabolite M4 Unclear MK-0822 [1]
MR003960 MK-0822 MK-0822 Metabolite M6 (Odanacatib) Multi-steps Reaction - Cyclization; Glutamyl removal; glutathione conjugation MK-0822 [2]
MR003961 MK-0822 MK-0822 Metabolite M9 (Odanacatib) Multi-steps Reaction - N-dealkylation; glucuronidation MK-0822 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003957 MK-0822 Metabolite M8 (Odanacatib) MK-0822 Metabolite M2-A Unclear MK-0822 [1]
MR003956 MK-0822 Metabolite M8 (Odanacatib) MK-0822 Metabolite M3 (Odanacatib) Conjugation - Glucuronidation MK-0822 [2]
MR003954 MK-0822 Metabolite M8 (Odanacatib) MK-0822 Metabolite M7-B (Odanacatib) Oxidation - Oxidationn MK-0822 [2]
References
1 Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway
2 Disposition and metabolism of the cathepsin K inhibitor odanacatib in humans. Drug Metab Dispos. 2014 May;42(5):818-27.

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