Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003972)
Formula
CYPIAE ...
SVG example
N-Dealkylation
Reactant NSC-38348 Product Theophylline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 IAE (CYPIAE) DME Info
Cytochrome P450 2EI (CYP2EI) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003971 NSC-38348 Demthyletamiphylline Oxidation - N-Demethylation NSC-38348 [1]
MR003970 NSC-38348 Desethyletamiphylline Oxidation - N-deethylation NSC-38348 [1]
MR003973 NSC-38348 Etamiphylline N-oxide Oxidation - N-oxidation NSC-38348 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000546 Caffeine Theophylline Oxidation - 7-N-Demethylation Caffeine [3], [4]
References
1 The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration
2 Identification of etamiphylline and metabolites in equine plasma and urine by accurate mass and liquid chromatography/tandem mass spectrometry
3 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.
4 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.