Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000546)
Formula
CYP1A2 ...
SVG example
7-N-Demethylation
Reactant Caffeine Product Theophylline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - 7-N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000544 Caffeine 1,3,7-Trimethyluric acid Oxidation - 8-Hydroxylation Caffeine [1], [2]
MR000543 Caffeine Paraxanthine Oxidation - Demethylation Caffeine [3], [2]
MR000545 Caffeine Theobromine Oxidation - 1-N-Demethylation Caffeine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003972 NSC-38348 Theophylline Oxidation - N-Dealkylation NSC-38348 [4]
References
1 PharmGKB summary: caffeine pathway. Pharmacogenet Genomics. 2012 May;22(5):389-95.
2 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
3 Pharmacokinetic analysis and comparison of caffeine administered rapidly or slowly in coffee chilled or hot versus chilled energy drink in healthy young adults Clin Toxicol (Phila). 2016;54(4):308-12. doi: 10.3109/15563650.2016.1146740.
4 The pharmacokinetics, metabolism and urinary detection time of etamiphylline in camels after intramuscular administration

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.