Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004018)
Formula
SVG example
P-oxidation
Reactant Unifac-6550 Product AA
Reactant Info Product Info
Metabolic Type Oxidation - P-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004023 Unifac-6550 10-EZ-HODE Oxidation - Oxidationn Unifac-6550 [1]
MR004021 Unifac-6550 12-ZE-HODE Oxidation - Oxidationn Unifac-6550 [1]
MR004022 Unifac-6550 13-ZE-HODE Oxidation - Oxidationn Unifac-6550 [1]
MR004020 Unifac-6550 9-EZ-HODE Oxidation - Oxidationn Unifac-6550 [1]
MR004019 Unifac-6550 DHA Oxidation - P-oxidation Unifac-6550 [2]
MR004014 Unifac-6550 Ketones Unclear Unifac-6550 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007504 Icosatrienoic acid Arachidonic acid Unclear Icosatrienoic acid [3]
MR004232 Dihomo--Linolenic Acid Arachidonic Acid Unclear Eicosadienoic acid [4]
MR007207 Dihomo-gamma-linolenic acid Arachidonic Acid Other reaction - Delta-5-desaturation Gamma-linolenic acid [5]
MR006390 Dihomo-gamma-linolenic acid Arachidonic acid Multi-steps Reaction - Elongation; desaturation Omega-6-FA [6]
References
1 Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells
2 Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate
3 The metabolism of dihomo-gamma-linolenic acid in man
4 Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. Mol Cell Biochem. 2011 Dec;358(1-2):85-94.
5 Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes
6 Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.

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