Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006390)
Formula
SVG example
Elongation; desaturation
Reactant Dihomo-gamma-linolenic acid Product Arachidonic acid
Reactant Info Product Info
Metabolic Enzyme Fatty acid desaturase 1 (FADS1) DME Info
Metabolic Type Multi-steps Reaction - Elongation; desaturation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007206 Gamma-linolenic acid Dihomo-gamma-linolenic acid Other reaction - Elongation Gamma-linolenic acid [1]
MR006389 Gamma-Linolenic acid Dihomo-gamma-linolenic acid Other reaction - Elongation Omega-6-FA [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007209 Dihomo-gamma-linolenic acid 15-HETrE Oxidation - Cyclooxygenation Gamma-linolenic acid [1]
MR007210 Dihomo-gamma-linolenic acid Prostaglandin E1 Unclear Gamma-linolenic acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007504 Icosatrienoic acid Arachidonic acid Unclear Icosatrienoic acid [3]
MR004018 Unifac-6550 AA Oxidation - P-oxidation Unifac-6550 [4]
MR004232 Dihomo--Linolenic Acid Arachidonic Acid Unclear Eicosadienoic acid [5]
References
1 Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes
2 Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.
3 The metabolism of dihomo-gamma-linolenic acid in man
4 Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate
5 Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. Mol Cell Biochem. 2011 Dec;358(1-2):85-94.

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