Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004095)
Formula
SVG example
O-demethylation
Reactant Norcodeine Product Normorphine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004094 Codeine Norcodeine Oxidation - N-demethylation Codeine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004806 Morphine Normorphine Oxidation - Demethylation Morphine [2]
MR004099 Morphine Normorphine Conjugation - Glucuronidation Codeine [3]
MR012869 Morphine Normorphine Unclear Ethylmorphine [4]
MR012873 Norethylmorphine Normorphine Unclear Ethylmorphine [4]
MR013334 Morphine Normorphine Oxidation - Demethylation Heroin [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012870 Normorphine Normorphine-3-glucuronide Unclear Ethylmorphine [4]
MR012871 Normorphine Normorphine-6-glucuronide Unclear Ethylmorphine [4]
References
1 Pharmacogenetics of analgesic drugs
2 Morphine: pharmacokinetics and clinical practice
3 Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers
4 Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20.

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