Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004099)
Formula
UGT2B7 ...
SVG example
Glucuronidation
Reactant Morphine Product Normorphine
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004807 Morphine Codeine Conjugation - Methylationn Morphine [1]
MR004808 Morphine Morphine ethereal sulfate Conjugation - Sulfation Morphine [1]
MR004804 Morphine Morphine glucuronide Conjugation - Glucuronidation Morphine [2], [3], [4]
MR004805 Morphine Morphine-3-glucuronide Conjugation - Glucuronidation Morphine [3], [2], [5]
MR004097 Morphine Morphine 3 glucuronide Conjugation - Glucuronidation Codeine [6]
MR004098 Morphine Morphine 6 glucuronide Unclear Codeine [6]
MR012874 Morphine Morphine-3-glucuronide Conjugation - Glucuronidation Ethylmorphine [7], [2], [3]
MR012875 Morphine Morphine-6-glucuronide Unclear Ethylmorphine [8]
MR013335 Morphine Codeine Conjugation - Methylationn Heroin [1]
MR013336 Morphine Morphine ethereal sulfate Conjugation - Sulfation Heroin [1]
MR013333 Morphine Morphine-3-glucuronide Conjugation - Glucuronidation Heroin [9]
MR013332 Morphine Morphine-6-glucuronide Conjugation - Glucuronidation Heroin [9]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004095 Norcodeine Normorphine Oxidation - O-demethylation Codeine [10]
MR012873 Norethylmorphine Normorphine Unclear Ethylmorphine [11]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012870 Normorphine Normorphine-3-glucuronide Unclear Ethylmorphine [11]
MR012871 Normorphine Normorphine-6-glucuronide Unclear Ethylmorphine [11]
References
1 Morphine: pharmacokinetics and clinical practice
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 Metabolism and pharmacokinetics of morphine in neonates: A review
4 Morphine metabolism, transport and brain disposition
5 Presence of morphine metabolites in human cerebrospinal fluid after intracerebroventricular administration of morphine
6 DrugBank(Pharmacology-Metabolism):Codeine
7 Metabolism of vitamin E in sheep
8 Aniline and its metabolites generate free radicals in yeast
9 PharmGKB:Heroin
10 Pharmacogenetics of analgesic drugs
11 Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20.

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