Details of the Drug Metabolite (DM)

General Information of Drug Metabolite (DM) (ID: DM003210)
DM Name
Morphine-3-glucuronide
Full List of Drug-Metabolizing Enzyme (DME) Related to This DM
DME(s) Producing This DM through Metabolism
DME Name DME ID Reactant Reaction Related Drug REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME0004
Morphine
Conjugation - Glucuronidation Morphine [2] , [3] , [4]
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME0075
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME0041
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME0042
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME0049
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME0066
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 2B4 (UGT2B4) DME0047
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
Morphine
Conjugation - Glucuronidation Heroin [1]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME0040
Morphine
Conjugation - Glucuronidation Morphine [2] , [3] , [4]
Full List of Drug(s) That Produce This DM By Metabolism
Morphine DR1112 Approved Anaesthesia
Heroin DR0807 Phase 3 Opiate dependence
Ethylmorphine DR0661 Investigative Discovery agent
References
1 PharmGKB:Heroin
2 Metabolism and pharmacokinetics of morphine in neonates: A review
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
4 Presence of morphine metabolites in human cerebrospinal fluid after intracerebroventricular administration of morphine

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