Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004429)
Formula Reactant 6-O-benzyl-8-oxoguanine Product 8-oxoguanine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Aldehyde oxidase (AOX1) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Debenzylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004428 O-Benzylguanine 6-O-benzyl-8-oxoguanine Oxidation - Oxidationn O-Benzylguanine [1]
References
1 Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. Clin Cancer Res. 2001 Dec;7(12):4239-44.

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