General Information of This Metabolic Reaction (MR) (ID: MR004628)
Formula
SVG example
Reactant Imipramine oxide Product Desipramine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004624 Imipramine oxide Imipramine Unclear Imipramine oxide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012986 Imipramine hydrochloride Desipramine Oxidation - N-demethylation Imipramine hydrochloride [2]
MR004625 Imipramine Desipramine Unclear Imipramine oxide [1], [3]
References
1 Imipramine metabolites in blood of patients during therapy and after overdose
2 Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
3 Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

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