Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012986)
Formula
CYP1A2 ...
SVG example
N-demethylation
Reactant Imipramine hydrochloride Product Desipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012989 Imipramine hydrochloride 2-hydroxyimipramine Oxidation - 2-hydroxylation Imipramine hydrochloride [1]
MR012991 Imipramine hydrochloride Didemethylimipramine Oxidation - Demethylation Imipramine hydrochloride [2]
MR012994 Imipramine hydrochloride Imidodibenzyl Metabolite Oxidation - N-dealkylation Imipramine hydrochloride [2]
MR012993 Imipramine hydrochloride Imipramine N-oxide Oxidation - N-oxidation Imipramine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004628 Imipramine oxide Desipramine Unclear Imipramine oxide [3]
MR004625 Imipramine Desipramine Unclear Imipramine oxide [4], [5]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Clinical pharmacokinetics of imipramine and desipramine
3 The kinetics of imipramine-N-oxide in rats
4 Imipramine metabolites in blood of patients during therapy and after overdose
5 Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine

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