Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004625)
Formula Reactant Imipramine Product Desipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004624 Imipramine oxide Imipramine Unclear Imipramine oxide [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004627 Imipramine 2-OH-imipramine Unclear Imipramine oxide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012986 Imipramine hydrochloride Desipramine Oxidation - N-demethylation Imipramine hydrochloride [2]
MR004628 Imipramine oxide Desipramine Unclear Imipramine oxide [3]
References
1 Imipramine metabolites in blood of patients during therapy and after overdose
2 Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
3 The kinetics of imipramine-N-oxide in rats

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