Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004749)
Formula
CYP2D6 ...
SVG example
5'-O-demethylation
Reactant Desglymidodrine Product Midodrine Metabolite M-2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 5'-O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004748 Midodrine Desglymidodrine Unclear Midodrine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004752 Desglymidodrine Midodrine Metabolite M-5 Unclear Midodrine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004751 Midodrine Metabolite M-2 Midodrine Metabolite M-4 Unclear Midodrine [1]
MR004750 Midodrine Metabolite M-2 Midodrine Metabolite M-6 Unclear Midodrine [1]
References
1 The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes

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