Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004840)
Formula
SVG example
Dealkylation
Reactant 3-OH-nabumetone Product 6-methoxy-2-naphthylacetic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004825 Nabumetone 3-OH-nabumetone Oxidation - Hydrolyzationn Nabumetone [1], [2], [3], [4], [5]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004826 3-OH-nabumetone O-desmethyl-3-hydroxy-nabumetone Oxidation - O-demethylation Nabumetone [2]
MR004830 3-OH-nabumetone Reduced 3-hydroxy-nabumetone Reduction - Reduction Nabumetone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004841 6-methoxy-2-naphthylacetic acid 6-hydroxy-naphthylacetic acid Oxidation - O-demethylation Nabumetone [3]
MR004844 6-methoxy-2-naphthylacetic acid 6-methoxy-naphthylacetic acid glucuronide Conjugation - O-glucuronidation Nabumetone [3]
References
1 Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35.
2 Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies: identification of new nabumetone metabolites
3 Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?
4 A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. Drug Metab Dispos. 2009 May;37(5):1017-24.
5 Identification of combined conjugation of nabumetone phase I metabolites with glucuronic acid and glycine in minipig biotransformation using coupling high-performance liquid chromatography with electrospray ionization mass spectrometry

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