Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000078)
Formula
PNP
SVG example
Phosphorylation
Reactant Inosine Product Hypoxanthine
Reactant Info Product Info
Metabolic Enzyme Purine nucleoside phosphorylase (PNP) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007514 Inosine IMP Unclear Inosine [1], [2]
MR007513 Inosine Unclear Unclear Inosine [1], [2]
MR000083 Inosine Adenosine phosphate metabolite Hx (hypoxanthine) Unclear Adenosine phosphate [3], [4], [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008771 Didanosine Hypoxanthine Unclear - Unclear Didanosine [6]
MR005024 Fluoxymesterone Fluoxymesterone Metabolite A7 Reduction - Reduction Fluoxymesterone [7]
MR004861 Naproxen Naproxen metabolite M1 Oxidation - Hydrolyzationn Naproxen [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005025 Fluoxymesterone Metabolite A7 Fluoxymesterone Metabolite A2 Oxidation - Hydrolyzationn Fluoxymesterone [7]
MR005026 Fluoxymesterone Metabolite A7 Fluoxymesterone Metabolite A8 Unclear Fluoxymesterone [7]
MR004862 Naproxen metabolite M1 Naproxen metabolite M2 Unclear Naproxen [8]
References
1 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
2 Inosine in Biology and Disease
3 Condition-dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis) J Food Sci. 2020 May;85(5):1462-1469. doi: 10.1111/1750-3841.15142.
4 Hypoxanthine Reduces Radiation Damage in Vascular Endothelial Cells and Mouse Skin by Enhancing ATP Production via the Salvage Pathway. Radiat Res. 2022 Jun 1;197(6):583-593. doi: 10.1667/RADE-21-00223.1.
5 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
6 Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes
7 Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry
8 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway

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