Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004869)
Formula
SVG example
Demethylation; Reduction
Reactant 5-methoxysalicylic acid Product Gentistic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 monooxygenase 51A (cyp51A) DME Info
Metabolic Type Multi-steps Reaction - Demethylation; Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004866 5-methoxysalicylaldehyde 5-methoxysalicylic acid Unclear Naproxen [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004867 5-methoxysalicylic acid Catechol Multi-steps Reaction - Demethylation; Reduction Naproxen [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006504 ANW-43703 Gentistic acid Oxidation - Aromatic hydroxylation ANW-43703 [2]
MR002995 Salicylic acid Gentistic acid Unclear - Unclear Aspirin [3]
MR006360 Salicylic acid Gentistic acid Unclear Salicin [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006505 Gentistic acid Gentisuric acid Unclear ANW-43703 [2], [5]
MR004870 Gentistic acid Maleylpyruate Unclear Naproxen [1]
References
1 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
2 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56.
3 Effect of common single-nucleotide polymorphisms in acetylsalicylic acid metabolic pathway genes on platelet reactivity in patients with diabetes Med Sci Monit. 2013 May 27;19:394-408. doi: 10.12659/MSM.883922.
4 Pharmacokinetics of salicin after oral administration of a standardised willow bark extract
5 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.