Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006504)
Formula
SVG example
Aromatic hydroxylation
Reactant ANW-43703 Product Gentistic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Aromatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006506 ANW-43703 Salicylacyl glucuronide Conjugation - Conjugation ANW-43703 [1], [2]
MR006507 ANW-43703 Salicylphenol glucuronide Conjugation - Conjugation ANW-43703 [1], [2]
MR006508 ANW-43703 Salicyuric acid Unclear ANW-43703 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002995 Salicylic acid Gentistic acid Unclear - Unclear Aspirin [3]
MR006360 Salicylic acid Gentistic acid Unclear Salicin [4]
MR004869 5-methoxysalicylic acid Gentistic acid Multi-steps Reaction - Demethylation; Reduction Naproxen [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006505 Gentistic acid Gentisuric acid Unclear ANW-43703 [1], [2]
MR004870 Gentistic acid Maleylpyruate Unclear Naproxen [5]
References
1 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56.
2 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
3 Effect of common single-nucleotide polymorphisms in acetylsalicylic acid metabolic pathway genes on platelet reactivity in patients with diabetes Med Sci Monit. 2013 May 27;19:394-408. doi: 10.12659/MSM.883922.
4 Pharmacokinetics of salicin after oral administration of a standardised willow bark extract
5 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway

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